Synthesis and Pharmacological Evaluation of Some Novel Isatin Derivatives for Antimicrobial Activity

Synthesis and Antimicrobial Activity of Some New Isatin Derivatives

Some new 3-[(5-benzylidene-2-phenyl)-3, 5-dihydro-4-H-imidazol-4-one-3-(4-bezoylhydrazono)]-indole-2-ones (VIII) have been synthesized from different isatinhydrazones (II) by condensing with 2-phenyl-5-benzylidene- 3-N (4-acetyl phenyl)-1, 5-dihydro-imidazol-4-one (VII). Their chemical structures have been confirmed by IR, 1HNMR, MASS and by elemental analysis. Investigation of antimicrobial ac...

Synthesis and Antimicrobial Activity of Some New Isatin Derivatives

Some new 3-[(5-benzylidene-2-phenyl)-3, 5-dihydro-4-H-imidazol-4-one-3-(4-bezoylhydrazono)]-indole-2-ones (VIII) have been synthesized from different isatinhydrazones (II) by condensing with 2-phenyl-5-benzylidene- 3-N (4-acetyl phenyl)-1, 5-dihydro-imidazol-4-one (VII). Their chemical structures have been confirmed by IR, 1HNMR, MASS and by elemental analysis. Investigation of antimicrobial ac...

Synthesis and Screening of Some New Isatin Containing Thiazole Derivatives for Antimicrobial Activity

In the present work, a series of new N’-[{5-(4-aryl) 1,3-thiazol-2yl}carbohydrazide-methyl]- 3(4-arylimino) indol-2-one analogs (5a-g) had heen synthesized from 3-(4-arylimino)-2-oxo- 1-indole-acetylthiosemicarbazide (4a-g) in ethanol, in the presence of phenacyl bromide or substituted phenacyl bromides. The compound 5e was characterized by its elemental analysis, IR, 1 HNMR and Mass Spectrosco...

synthesis and antimicrobial activity of some new isatin derivatives

some new 3-[(5-benzylidene-2-phenyl)-3, 5-dihydro-4-h-imidazol-4-one-3-(4-bezoylhydrazono)]-indole-2-ones (viii) have been synthesized from different isatinhydrazones (ii) by condensing with 2-phenyl-5-benzylidene- 3-n (4-acetyl phenyl)-1, 5-dihydro-imidazol-4-one (vii). their chemical structures have been confirmed by ir, 1hnmr, mass and by elemental analysis. investigation of antimicrobial ac...

synthesis and screening of some new isatin containing thiazole derivatives for antimicrobial activity

Synthesis, characterization and biological activities of some novel isatin derivatives

A series of novel (arylimino-2-oxo-2,3-dihydro-indol-1-yl)-acetic acid N'-(4-aryl-2-yl)-hydrazide derivatives (5a-g) were synthesized. The structures of the newly synthesized compounds were characterized by elemental analysis, FT-IR, H-, C-NMR and mass spectroscopy. The compounds were screened in vitro for antibacterial and antifungal activities against some human pathogenic microorganisms by t...